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Research has shown that alcohol stimulates hepatocytes to release extracellular vesicles containing CD40L in a caspase-3-dependent manner [167], thereby activating macrophages and increasing the production of inflammatory cytokines

10.1016/s0006-291x(00)90000-7 [DOI] [PubMed] [Google Scholar] Harms N., Ras J., Reijnders W

Tosic M, Ott J, Barral S, Bovet P, Deppen P, Gheorghita F, et al

Worthington HV, Hunt LP, McCloy RF, Maclennan I, Braganza JM

p63 is a member of the tumor suppressor family which includes p53 and p73 and while it was discovered much later than the others, p63 appears to be the original member of this family from which p53 and p73 evolved [14-17]