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Innate immunity and neurodegeneration

92 It also promotes expression of aggrecanases ADAMTS-4 and ADAMTS-5, with histological assessments confirming proteoglycan loss following LEP treatment

Leckstrom, A., Bjorklund, K., Permert, J., Larsson, R

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In November 2012, cabozantinib, a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, was approved for thyroid cancer [56] and also in April 2016 was accepted as second-line treatment for RCC [57]