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A recent study characterized 21 human SLC39A8 variants and further demonstrated that different missense mutations can variably impair Mn uptake, linking specific genetic variation to functional deficits (Wang et al., 2025)

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Purity, potency, and consistency are real safety issues, particularly for injectable products. She says that at a minimum, safeguards should include ingredient sourcing, supplier qualification, identity testing, purity, potency, sterility, endotoxin testing, stability, labeling, and adverse event reporting