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All such findings are observations drawn from controlled preclinical, in-vitro, and animal research and are reported here solely to describe the compound's investigational context

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doi: 10.1016/j.neuroscience.2013.11.026

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While these agents often spare normal proliferating tissues, they introduce new toxicity patternssuch as dermatologic reactions, QT prolongation, diarrhea, and hepatotoxicityoften linked to the pathways they target in normal tissues