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If you are vegan, poorly digesting or absorbing foods such as having chronic gastritis, Crohns disease, or ulcerative gastritis, or if you have an autoimmune disorder such as Graves disease or lupus you can be deficient in vitamin B12

The FIC index is calculated as FIC + FIC = (MIC of drug A in combination / MIC of drug A alone) + (MIC of drug B in combination / MIC of drug B alone)