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Because CGRP is essential for bone healing, the potential negative impact of these medications on bone regeneration warrants clinical investigation

They also act on the digestive system to delay gastric emptying, delaying the release of food from the stomach and modulating brain activity to suppress appetite

Statements Author contributions CH: Conceptualization, Formal Analysis, Writing original draft, Writing review and editing

Participants received weekly subcutaneous injections of survodutide at 2.4 mg, 4.8 mg, or 6.0 mg, or placebo

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Animals were euthanised via pithing (brain destruction), and testicular tissue extracted for the present study according to the protocols approved by the University of Wollongongs Animal Ethics Committee, protocol number AEPR231