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The resulting strong inflammatory response promoted the formation of inducible TLS (iTLS) and significantly enhanced immunotherapy

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One group was fed the control diet and another group was fed the cystine-supplemented diet (n = 14 per diet)

Furthermore, a conjugate formation assay, utilizing Jurkat T cells, Raji B cells as APCs, and staphylococcal enterotoxin (SEE) as a TCR stimulant, followed by fluorescent cell staining and confocal microscopy confirmed that phospho-Thr 335 is required for PKC localization at the IS ( Figures 1I, J )

Figure 1 summarizes the key diabetes-related factors associated with the development of T1D, T2D, and DR