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Malaria parasites are constantly exposed to high fluxes of toxic reactive oxygen species (ROS) and to counter this they have developed elaborate redox systems comprising of thioredoxins, peroxoredoxins, glutathiones and superoxide dismutases amongst others 2

Corsini EM, Mitchell KG, Zhou N, Antonoff MB, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG , Vaporciyan AA, Walsh GL, Maru DM, Lin SH, Ajani JA, Hofstetter WL

For patients also at risk for fatty liver disease which is directly driven by visceral fat and hepatic lipid accumulation the upstream VAT reduction may offer hepatic benefits as well

(1986) reported positive results in strains TA98 and TA100 without specifying dose levels or revertant rates