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Of note, Cef has been shown not only to induce EAAT2 expression but also to activate the transcription factor Nrf2 (Lewerenz et al., 2009), which induces the transcription of a plethora of genes involved in cytoprotection and antioxidant defense (Kensler et al., 2007)

Coffee consumption decreases the connectivity of the posterior Default Mode Network (DMN) at rest

doi: 10.1038/s41392-023-01471-y 11 CucheCMastrogiovanniMJuzansMLaudeHUngeheuerMNKrentzelDet al

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It also prevents the incidence of long term complication in diabetic nephropathy [103, 119, 126, 127]