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114 Bongiovanni, D

Reduced synaptic input from photoreceptors can lead to morphological abnormalities at photoreceptor synapses and the interconnectedness between photoreceptors and bipolar cells is essential for their homeostasis and survival [[88], [89], [90]] Rod bipolar cells are some of the first cells to exhibit aberrant behavior and ectopic connections in retinal degenerative diseases [[90], [91], [92]] such as retinitis pigmentosa

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Neuropathological hallmarks of the disease include the abnormal deposition of amyloid -peptide (A) fibrils, the main component of senile plaques (SPs), and the intracellular accumulation of neurofibrillary tangles (NFTs), composed of hyperphosphorylated Tau protein (pTau)

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This was attributed to its serotonergic action and increased release of central neurotransmitters including norepinephrine and serotonin