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3-Bromopyruvate (3-BP), also known as hexokinase II inhibitor II, has shown promise as an anticancer agent against various types of cancer [13]

This positive aspect might be explained by the capability of bioactive molecules to block complex III of OXPHOS, phosphodiesterase or ATP synthase, thus contributing to the activation of AMPK cascade (Park et al

J Toxicol Environ Health B Crit Rev 11(1):115

Pentoxifylline attenuates tubulointerstitial fibrosis by blocking Smad3/4-activated transcription and profibrogenic effects of connective tissue growth factor

[DOI] [PubMed] [Google Scholar] 568.Nicholson MW, Ting C-Y, Chan DZH, Cheng Y-C, Lee Y-C, Hsu C-C, et al

however, it is sometimes difficult to diagnose AIP due to difficulties associated with the small samples that are involved