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A 2023 systematic review looked at CBD and insomnia symptoms and called for better trials

No major toxicological red flags have been identified in preclinical studies

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Conversely, overfeeding increases intra-portal insulin levels that enhances hepatic GH sensitivity to a degree where relatively low GH secretion is sufficient to maintain ambient hepatic IGF-I synthesis and secretion, and normal circulating IGF-I levels ( Figure 1 This review summarizes how changes in hepatic exposure to intra-portal insulin in health and disease states modulates the GH/IGF-I axis