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Furthermore, the p53-induced phosphatase TIGAR, which supports intestinal oxidative defence and nucleotide synthesis 42,43 , may promote PPP flux by dephosphorylating the PFK activator fructose 2,6-bisphosphate and/or the downstream glycolytic metabolite 2,3-biphosphoglycerate 44

While people with elevated homocysteine may benefit from dietary interventions and supplementation (especially if the elevation was caused by inflammatory foods and nutrient deficiencies), other reasons for inflammation should be investigated with your practitioner as well

Tolia A, De Strooper B

In MM cells, GLUT1 upregulation increases glucose uptake and enhances susceptible to GLUT1 inhibitors (61)