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As to the pi class, GSTP1-1 point mutations in both exon 5 (codon 105) and exon 6 (codon 114) were observed and shown to have an impact on the enzymatic activity 32

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Specifically, neither the precise intracellular processing of the GLP-1/E2 conjugate, which results in active estrogen cargo release, nor the molecular identity that delivers estrogen activity, have been determined