2000gm l carnitine per day uses l-carnitine: Nutrition, pathology, and health benefits L-Carnitine | Linus Pauling Institute

The American College of Rheumatology recommends that patients should be screened for chronic infection and latent tuberculosis before starting treatment of rheumatoid arthritis with any DMARD, including methotrexate (Wasserman 2018)

It may also be useful for other peripheral neuropathies

Adding guanfacine likely provides a potentiating synergistic benefit of activating the a2A-adrenergic receptors and increasing the postsynaptic signal in DLFPC Layer III pyramidal neurons

By splitting the dose, people hope to give their digestive system more than one chance to pick up the nutrient

Redox Signal 17, 4557

A 3-gram dose ten times what most supplements contain showed zero increase.[5] Verdict: Doesnt work