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Upregulation of carbonyl reductase 1 by nrf2 as a potential therapeutic intervention for ischemia/reperfusion injury during liver transplantation

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IGF1/2 binds to IGF-IR homodimer and IGF-IR/InsR heterodimer

The lipid-derived electrophiles MDA and HNE were shown to alkylate DNA bases and protein thiols leading to DNA and membrane damages in eukaryotes (Rudolph and Freeman, 2009)