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This metabolic shift enables GBM cells to maintain ATP production, generate biosynthetic intermediates, and manage redox balance even in oxygen-poor environments

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In hypercholesterolemic patients with moderate CVD risk, another nutraceutical containing berberine and red yeast rice yielded lower LDL and triglycerides with better tolerance than with ezetimibe, but did not affect HDL (21)

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The inactivation of GPX4 can be achieved through both indirect approaches, including GSH depletion, as well as direct methods involving pharmacological or genetic interventions