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Autoimmunity and oxidatively modified autoantigens

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Recently, mutations in DEPDC5 were also observed in autism spectrum disorders , 424 as were mutations in NPRL3 in Parkinsons disease, 425 suggesting a broader neurological impact of GATOR1 dysfunction

These activities occur both through direct protein-disulfide reductions and via the transfer of this reducing power to Trx-dependent peroxiredoxins and methionine sulfoxide reductases [48, 49], or to GSH-dependent glutathione peroxidases [43]

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Carlsson L, Ronquist G, Stridsberg M, Johansson L (1997) Motility stimulant effects of prostasome inclusion in swim-up medium on cryopreserved human spermatozoa