Note: If you experience swelling of the face, lips, or tongue, difficulty breathing, or widespread hives, call 911 or go to the nearest ER immediately
To elucidate which proteins are susceptible to carbonylation in -cells in T1D settings, we recently mapped over 1000 individual carbonylated proteins in islets from pre-diabetic NOD mice side by side with MIN6 -cells treated with 4-HNE or cytokines ( Table 1 ), including, Sec61 translocon subunit alpha 1 (SEC61A1), ADP ribosylation factor 1 and 3 (ARF1, 3), RAB3 GTPase activating protein catalytic subunit 1 (RAB3GAP1), N ethylmaleimide sensitive factor (NSF), RAB18, member RAS oncogene family (RAB18), Syntaxin binding protein 1 (MUNC18-1), RAB7A, member RAS oncogene family (RAB7A), Syntaxin 5 (STX5), Adaptor related protein complex 2 subunit alpha 2 (AP2A2), Endoplasmic reticulum Golgi intermediate compartment 1 (ERGIC1), Dynamin 1 like (DNM1L), Transmembrane p24 trafficking protein 10 (TMED10), Post GPI attachment to proteins 1 (PGAP1) and JNK interacting protein 4 (JIP4) (182), we observed insulin (INS2) carbonylation upon exposure to 4-HNE (183)
For instance, Jessica C
Future studies using post-treatment designs (inducing damage first, then administering DBD) would be needed to evaluate potential therapeutic effects on already-damaged cells
(PubMed) American College of Obstetricians and Gynecologists (ACOG)
As far as we know, in an ovarian cancer context, those micelles have not been tested yet, but we predict that the response of ovarian cancer cells to those micelles would differ between histological types, in which OCCC cells that are more dependent on thiol metabolism would be even more suitable for this delivery system
