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Glossary AMD age-related macular degeneration DR diabetic retinopathy RP retinitis pigmentosa ROS reactive oxygen species RPE retinal pigment epithelial cells RGC retinal ganglion cells I/R ischemia-reperfusion ACSL4 acyl-CoA synthetase long-chain family member 4 SD Stargardt disease atRAL all-transretinal GSH glutathione MDA malondialdehyde pH IOP pathological high intraocular pressure NMDA N-methyl-D-aspartate HRCECs human retinal capillary endothelial cells PM2.5 airborne fine particulate matter HRMECs human retinal microvascular endothelial cells OT Ocular toxoplasmosis CPT1 carnitine palmitoyltransferase I TCM traditional Chinese medicine DFO deferoxamine LDH lactate dehydrogenase DFP deferiprone FDA Food and Drug Administration TF transferrin Fer-1 ferrostatin-1 atRA all-trans-retinoic acid AS-IV astragaloside IV LOX lipoxygenase RIPK receptor-interacting protein kinase ATC Anatomical Therapeutic Chemical References 1 AmagaseH.SunB.BorekC

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Final model performance was evaluated on the hold-out set and assessed by fold-improvement over incidence of AATD-LD observed in the IQVIA AEMR data

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