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Kiemer AK, Bildner N, Weber NC, Vollmar AM

Hijov, 2025)

Geroscience 45 , 21352143 (2023)

Likewise, in the hippocampus, depressed rats showed hippocampal atrophy and dilated ventricles as well as apoptotic neurons

Circulating dopamine activates the Gs-cAMP-PKA pathway by binding to the D1R receptor on immune cells, further inhibiting NF-B and the NLRP3 inflammasome, reducing the levels of inflammatory factors such as TNF- and IL-1, and improving the systemic and pulmonary inflammatory responses (182)