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Moreover, although resveratrol is generally well-tolerated at doses of up to 1 g/day, safety concerns regarding potential estrogenic stimulation in hormone-sensitive tissues remain a barrier to long-term studies in populations with hormone-sensitive conditions

Preclinical studies (in vitro and animal) reveal mechanistic benefits such as gut microbiota modulation, improved barrier function, and metabolic regulation

Such disturbances could potentially lead to decreased disulfide bond formation (Plowman et al

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Estrogen is a beneficial hormone during the fertile periods of the menstrual cycle and plays a role in preparing the body for pregnancy

Naganuma, A