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Library quantification was performed for quality control before sequencing by using the Agilent Technologies 2100 Bioanalyzer

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Meta-analysis revealed no statistically significant difference in the incidence of any specific adverse event between the two groups, including abdominal pain, constipation, increased appetite, decreased appetite, headache, rashes, sedation, irritability, aggressions, insomnia, self-injurious behavior, diarrhea, and anxiety