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The liver normally stores up large amounts of B 12

Similar compounds are produced by reactions that break down the structure of NAD, providing a salvage pathway that recycles them back into their respective active form

In the model of severe infection or sepsis, hematopoietic stem and multipotent progenitor cells (HSPCs) in the BM are also activated to proliferate and prompt BM hematopoiesis, facilitating infection control (246, 247)