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FIGURE 4 While oxidative stress represents a fundamental mechanism in red blood cell (RBC) senescence, it is not the exclusive driver of this process

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Acute altitude illnesses (AMS, HACE, and HAPE) stem from inadequate acclimatization, whereas chronic conditions (CMS and HAPH) reflect prolonged or excessive adaptive responses

Other compounds in antioxidant-rich foods may play vital roles in the antioxidant effects of whole foods, producing effects that cannot be replicated with a synthetic, isolated antioxidant

GSH is essential for immunomodulation of both innate and adaptive immune system functions, including T-lymphocyte proliferation, polymorphonuclear neutrophil phagocytosis, and dendritic cell functions, and is also important for fine-tuning the innate immune response to infection and for the first step of adaptive immunity involving antigen-presenting cell (macrophages, dendritic cells)-related antigen presentation (Morris et al., 2013