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While not typically causing classical HCU, these variants can worsen biochemical imbalances in genetically predisposed individuals (2729)

Furthermore, HF leads to endothelial dysfunction in various tissues, including skeletal muscles, as a result of reduced NO production by endothelial NO synthase [18]

81 Di MarzioD

Whilst promising results were seen, there was a propensity for the potential compounds to cyclize (Zhang et al., 2013a,b) suggesting that NHG conjugation to GSH may be more stable

Nature 603 , 885892 (2022)