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In addition, TAZ increased SLC7A11 (Fig

10.1016/j.jff.2021.104661 9 B.CarlP.Patel (Editors) (2014)

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however, a remaining challenge is the ability to selectively induce ferroptosis in HSCs with minimal effects on healthy hepatocytes

Though Murcko scaffolding represents the skeleton of a molecule, it is possible that side chains may also play an important role in substrate recognition by the TolC-related efflux pumps that are not captured in the scaffold-based analysis