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Avoiding smoking should also be part of the changes, as it has been linked to MASLD, fibrosis progression and HCC (256)

Acknowledgements The authors thank A

Synapse 67 (5), 245257

mori (XP_012549788.1 and XP_004930722.1) fits the hypothesis of a novel VC synthesis pathway, identical to that of vertebrates, with the exception of the enzyme involved in the last step of the pathway [20]

These large aggregates turn out to be inaccessible to proteasomal proteases, so they are stored in the aggresome and are then degraded via macroautophagy (Fig