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Laurent, C

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Furthermore, as trauma is undoubtedly at the origin of PD and even micro-injuries may bear serious consequences in genetically predisposed patients, even injections must be considered a source of microtrauma for the tissues, therefore we made sure to use a very thin needle when performing the injections in the area around the plaque, and we decreased the number of injections at every treatment cycle

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Hening, W., Allen, R., Washburn, M., Leasage, S

Pharmacovigilance best practice is to train sites on seriousness triggers before enrollment and reinforce that incomplete information should never delay initial reporting when SAE criteria may be met