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These disruptions can impair synaptic function by interfering with proper intracellular trafficking, signaling, and communication in neurons, contributing to the early pathology of sporadic AD (Marquer et al., 2014

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the effect may be synergistically enhanced

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Among HBV CA inhibitors, several drugs have entered phase II clinical trials, with GLS4 being the first nucleocapsid inhibitor to enter phase III clinical trials globally