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Randomized trials show mixed results in terms of risk for adverse effects and great variability in the dosage used in trials may be partly to blame

Ongoing research is targeting other areas of the body for treatment and the preliminary results are very encouraging

It is noteworthy that this trial was conducted during the COVID-19 pandemic and reported an unusually high placebo response rate, probably amplified by behavioral, dietary, and psychosocial changes (110, 124)

11 Thats especially relevant for women, since both estrogen and growth hormone decline with age, causing skin to become thinner and less elastic over time

TNF- upregulates epithelial adhesion molecules, promotes inflammatory cell recruitment and activation, and induces inflammatory mediator release, resulting in tissue damage [98]

J Dermatol 45(6):692700