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The combination of viral persistence, microbiome dysbiosis, and localized inflammation inevitably leads to the degradation of the intestinal barrier, a condition clinically known as intestinal hyperpermeability, or "leaky gut." The intestinal lining is only one cell thick, and these cells are glued together by complex protein structures called tight junctions

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Targeting PTDSS1 leads to GSH depletion and mitochondrial dysfunction PS catalyzed by PTDSS1 is crucial for maintaining mitochondrial functional stability and cellular structural homeostasis [16, 28]

Time Point 12 months What Trials Saw Lancet HIV NAFLD trial: liver-fat reduction of about 32% versus placebo, with lower fibrosis progression

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