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Biology of the heat shock response and protein chaperones: Budding yeast ( Saccharomyces cerevisiae ) as a model system Microbiol

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Epidemiological data indicate that the incidence of AP continues to rise worldwide, emphasizing its substantial clinical and socioeconomic burden ( The pathogenesis of AP is multifactorial and involves a complex interplay of premature intracellular enzyme activation, calcium overload, oxidative stress, inflammatory signaling, immune dysregulation, and mitochondrial damage in pancreatic acinar cells (PACs) (5)

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