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CNS-resident cells, in collaboration with peripheral immune cells, produce a variety of inflammatory mediators which recruit inflammatory cells into the CNS which eventually cause demyelination and trigger inflammation in the CNS as shown in Fig

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Furthermore, a long loop (residues 300311) that links the fourth and fifth blades of c-MET I-SEMA adopts an extended conformation, is tethered to the K3 domain of HGF I, which largely contributes to the binding between c-MET I-SEMA and HGF I-K3 (Fig

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