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Statements Author contributions CHM, DMI, and AHJ conceived, outlined, and wrote the review

C4a also induces the generation of reactive oxygen species (ROS) via NADPH oxidase, contributing to oxidative stress, mitochondrial dysfunction, and downstream redox-sensitive signaling cascades such as NF-B and AP-1

* Correspondence: Monica Barne, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Homoscedasticity was assessed by visual inspection of residual plots