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In the present study, it is presumed that autophagy is induced by increased oxidative stress in EAAC1 and GLAST KO mice, and NAC suppressed autophagy and promoted RGC protection by reducing oxidative stress

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The samples were incubated at room temperature (25 C) on a shaker (100 rpm) for 24 h

Senescence mechanisms and targets in the heart

The mTORC1-S6K1 axis also promotes phosphorylation of SRPK2 (SRSF protein kinase 2), and, in concert with its phosphorylation by CK1 (casein kinase 1), induces SRPK2 nuclear translocation and the splicing of lipogenic-related transcripts (Lee et al., 2017)