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DPP-IV resistance is achieved through an -aminoisobutyric acid (Aib) substitution at position 2, blocking the proteolytic cleavage that normally inactivates incretin peptides within minutes of secretion

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For detection, the HPLC was equipped with a series diode array (DAD)

Cho Y, Joshi R, Lowe P, Copeland C, Ribeiro M, Morel C, et al

In 1989 a subcommittee of the United States Food and Nutrition Board, National Research Council, issued its last update on recommended dietary allowances (RDA) for protein and amino acids (These recommendations rely on N balance studies performed many years ago [24]

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