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A meta-analysis that included 27 trials involving 2,562 BC patients showed that Huaier Granule in combination with conventional therapy significantly improved overall response and quality of life, prolonging OS and DFS at 2 and 5 years, in addition to a significant enhancement of immune function in patients following the combined intervention, with the percentage of CD3 + , CD4 + , and natural killer cells and the CD4 + /CD8 + ratio were significantly higher