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Excess hydroxocobalamin can bind to other plasma proteins such as albumin, which helps explain the very high B12 levels seen after injections of that form

The previous guideline advised doctors that patients with Pernicious Anaemia can safely have their injections stopped for a year as they will have sufficient stores of B12 in their liver

The relationship between NAM metabolism and NAD + utilization indicates that elevated NNMT expression may inhibit energy expenditure and promote fat deposition by limiting NAD + -dependent processes (Trammell and Brenner, 2015)