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DRUG INDUCED ACCUMULATION OF mtDNA DAMAGE Because mitochondria contain their own DNA, mitochondrial genome integrity is essential for organelle function

It can also be taken as a supplement as a liposomal formulation or in the form of S-acetyl-glutathione, although these also appear to have limited impact on raising glutathione levels in the body

10.1002/art.39795 [DOI] [PMC free article] [PubMed] [Google Scholar] 47

In conclusion, we suggest that APR-246 exerts its cytotoxic effect through various cell death pathways

Testing antiretrovirals of the different classes according to their toxicity indexes resulted in an observation that the drug inducing the highest compromise of mitochondrial membrane potential was previously established as the least toxic, whereas the previously established most toxic drugs had variable effects of either decreasing or increasing mitochondrial membrane potential (Robertson et al

Riederer P, Nagatsu T, Youdim MBH, Wulf M, Dijkstra JM, Sian-Huelsmann J