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NaHS treatment elevated the ubiquitination level of Kelch-like ECH-associated protein (Keap1) by preserving its E3 ligase synoviolin (Syvn1), resulting in Nrf2 nuclear translocation

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A 2022 clinical study evaluated oral Alpha-Lipoic Acid (ALA) as a chelator in human patients over three months

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This is further supported by the study of Yang, Huang (102) in which the significant induction of cytokines, chemokines, and adhesion molecules (such as TNF-, IL-1, MCP-1, CXCL1, ICAM-1, VCAM-1) in human brain microvascular endothelial cells by SARS-CoV-2, suggesting an activation of the vascular endothelium in the brain