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Cynaroside interventions significantly inhibited a variety of cytokines and related receptors involved in the inflammatory pathway, the chemokines and their receptors that were downregulated included C-C motif ligand (CCL)1-3, CCL19, CCL21, C-C motif receptor (CCR)7, CCR8, C-X-C motif chemokine ligand (CXCL)2, CXCL8, CXCL9 and CXCL12

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Recent studies (2023-2025) have demonstrated that IL-17A directly upregulates pro-ferroptotic mediators such as ACSL4 while suppressing protective factors like myocyte enhancer factor 2C (MEF2C) in airway epithelium, thereby creating a feed-forward loop of lipid peroxidation (129131)