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p53 promotes cell survival due to the reversibility of its cell-cycle checkpoints

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Mammalian cells have enzymes like Nudix hydrolase 1 (NUDT1, MTH1) that remove these nucleotides from the pool, hydrolyzing 8-oxoGDP to 8-oxoGMP, with MTH1 also acting on 8-oxoGTP

Tissue-related and regenerative research models where structural integrity, matrix remodeling, or barrier function are endpoints

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This combination markedly reduces TrxR activity and GSH levels, promoting the release of HMGB1 and other DAMPs, which promote DC maturation and enhance immunogenicity