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Many EDS patients have shared that prolotherapy provided relief when nothing else did, for example, alleviating chronic neck pain from cervical instability or reducing the frequency of knee cap dislocations by tightening the surrounding ligaments

Levels of the enzymes glutathione peroxidase and SOD and of the nonenzymatic components of the antioxidant system including reduced glutathione, ascorbic acid, -tocopherol, lycopene, and -carotene were significantly lower in children with asthma compared with the healthy controls

Gualtieri, R

& Aba-Mondoloni, J

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These variants, defined by allele frequencies exceeding 1% in the population, may not cause overt disease but can modulate enzyme activity, folate status, and susceptibility to complex conditions