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Activation of the nuclear factor erythroid 2related factor 2 (Nrf2) pathway directly raises GSH levels, upregulates the transcription of genes involved in antioxidant defense, provides mitochondrial protection, facilitates the proliferation of detoxification enzymes and modulates neuroinflammation (Guerrero-Beltrn et al., 2012

For instance, SKF 83822 is a functionally selective ligand biased towards D 1 -mediated signaling via adenylyl cyclase, that additionally causes seizures at high doses, 64 while SKF 83959 preferentially activates the D 1 /D 2 receptor heteromer and the associated phospholipase C response

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