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showed that GSH is required for cancer initiation partially because of the upregulated activation of the thioredoxin (TXN) antioxidant pathway and inhibition of both GSH and TXN pathway activation, synergistically inhibiting tumor growth 26

10.1021/acs.chemrev.7b00181 5 AltmanB

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Bochicchio D, Pavan GM

Pre-exercise glutamine administration may prevent the decrease in circulating glutamine during strenuous exercise, support enterocyte energetics to mitigate exercise-induced gastrointestinal syndrome, and prime antioxidant defenses and HSP responses to reduce acute oxidative and inflammatory damage

Patent applications on the work described in this paper may be filed by Johns Hopkins University