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However, the net effect of any single metabolite is profoundly context-dependent, governed by its concentration gradient, spatial distribution within the TME, host genetics, and the constellation of other present signals

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Still, that does not mean injections are right for everyone, nor should they be treated casually

Oxidized or glycated LDL can sabotage endothelial mitochondrial function and damage the endothelial barrier, setting the stage for the atherosclerotic cascade to initiate

Moreover, the other inflammatory cytokines like adhesion molecules would result in vascular dysfunction and consequently neuropathic pain (13)