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In the AF-2 core region (894-EMMAEIIS-901) of the androgen receptor ligand-binding domain a relatively low number of mutations have been reported [see Figure 10 for location of AF-2]

doi: 10.3390/pharmaceutics17010129, 91

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This pathway has thus been connected to both regenerative medicine, because of its role in development and tissue growth, and cancer, because of its influence on proliferation and cell survival (225, 226)