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This synergy is commonly used during advanced growth or recomposition cycles

Schmolke, M., Bornemann, A

Mizuno Y, Kagitani-Shimono K, Jung M et al (2019) Structural brain abnormalities in children and adolescents with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder

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In the lean stack protocol , it provides targeted GH stimulation by: Selectively triggering GH release without significant cortisol or prolactin elevation Creating a synergistic GH pulse when combined with CJC-1295 Supporting lipolysis through GH-mediated mechanisms Preserving muscle protein synthesis during energy deficit research Having a short half-life (~2 hours) allowing precise dosing timing Unlike older GH secretagogues, Ipamorelin does not significantly raise acetylcholine, cortisol, aldosterone, or prolactin making it the cleanest option for the lean stack protocol