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3.3 Melatonin inhibits cellular apoptosis Oxidative stress is a potent apoptotic inducer, which disrupts Ca 2+ homeostasis, causes mitochondrial dysfunction, e.g., mtDNA damage and cytochrome c release, and induces typical apoptotic proteins, e.g., the increased expression of cleaved caspase-3 (CASP3) and B-cell lymphoma 2 (BCL2) and the decrease in the bcl-2-like protein 4 (BAX) content ( 3 K)akt serine/threonine kinase 1 (AKT1) signaling pathway (Shen et al., 2017)

Functional hypothalamic amenorrhea: gut microbiota composition and the effects of exogenous estrogen administration

[DOI] [PMC free article] [PubMed] [Google Scholar] 107

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EVs in the gastrointestinal system contain various molecular components depending on their progenitor cells, which determine EVs activity (Li et al., 2023)